Effect of Permeation Enhancer on Bioavailability of Formulated Patches of Glibenclamide

Objectives: The objective of this study is to extract Phytochemical constituent from Cinnamon Bark and design develop the transdermal patch herbal drug along with modern medicine Glibenclamide using solvent casting method reduce dose required obtain same pharmacological effect, also toxicity drug. Methods: Transdermal patches were formulated by method. physical chemical similarity medication base studied Infrared Spectroscopy (FTIR). outcomes recommended no properties incongruence between base. assessed for weight difference, fatness, folding endurance, wetness, moisture captivation, ex vivo release, absorption. Results: diffusion examines performed utilizing Franz cell everted gut sac best formulation F5 showed Thickness 0.230±0.009mm, Weight uniformity 0.170±0.021gm, % Moisture uptake 8.307±1.00 content 5.045±0.214, Drug 80.80±0.091, Folding endurance27±4.50. Formulation exhibits highest cumulative release 67.90±1.01% in 8hrs %Drug absorbed 4.263±0.41 120 min. Conclusion: It can be concluded no. shows maximum bioenhancing action compared all other which contains Ethanolic bark.